SofaRun is an MSX tool designed to run disk (.DSK), cassette (.CAS) and cartridge (.ROM) images. Various settings can be set and stored for each game. It can also be used to launch normal MSX-DOS 2 and BASIC programs.
It features a joystick controlled file browser, ZIP files support, options to map JoyMega buttons to keyboard and "soft reset", allowing you to play lying on your sofa just like a lazy penguin!
You can grab it here:
Please report any issue on the SofaRun bug report thread.